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Hamaguchi Lab.

Spectrophysical Chemistry bridges chemistry and biology


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1064nm Near-Infrared Excited Raman Spectroscopic System

1064nm Near-infrared Excited Raman Spectroscopic System

Fig. 1

Fig. 1. Apparatus

Fig. 2

Fig. 2. Setup

The Effect of 1064nm Near-infrared Excitation

We can eliminate the background fluorescence by using near-infrared excitation.

Fig. 3

Fig. 3. Comparison of the Raman spectra of the same lung cancer tissue

It is necessary to use 1064nm excitation for Raman measurment of biological samples, such as fresh lung tissues, human skin and so on.


Fig. 4

Fig. 4. Typical standard Raman spectra representing fresh (blue line) and cancerous (red line) lung tissues. Extracted from the 530 accumulated Raman spectra of 35 lung cancer patients. Experimental condition: 38 mW/5min
A marked difference is found at the 1659 cm-1 band of the amide I vibration.

It can be used as criteria for distinguishing normal and cancer lung tissues.


  1. Y.-K. Min, T. Yamamoto, E. Kohda, T. Ito, and H. Hamaguchi, J. Raman Spectrosc. 2005, 36, 73-76.

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