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Hamaguchi Lab.

Spectrophysical Chemistry bridges chemistry and biology

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Hiro-o Hamaguchi, Professor

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Education and Professional Experience

1970 B. S. (Chemistry), The University of Tokyo
1975 D. Sc. (Chemistry), The University of Tokyo
1975 Research Associate, The University of Tokyo
1981 Lecturer, The University of Tokyo
1983 Associate Professor, The University of Tokyo
1990 Laboratory Head, Kanagawa Academy of Science and Technology
1995 Professor, Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo
1997 Professor, Department of Chemistry, School of Science, The University of Tokyo (Structural Chemistry)
2007 Chair Professor, College of Science, National Chiao Tung University

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Professional Service

  1. International Journals
    • Chemical Physics LettersiElsevier), Editorial Advisory Board (1988-2008).
    • Bulletin of the Chemical Society of Japan, Editorial Advisory Board (1988-1990).
    • Laser ChemistryiGordon & Bleach), Editorial Advisory Board (1992-2002).
    • Chemical PhysicsiElsevier), Editorial Advisory Board (1992-present).
    • Journal of Raman SpectroscopyiWiley), Associate Editor (1997-present).
    • Chemistry Letters, Editorial Advisory Board (1997-2000).
    • Applied Spectroscopy, Associate Editor for Japan (2000-2009).
    • Journal of Molecular Structure (Elsevier), Editorial Advisory Board (2004-present).
  2. International Conferences
    • The KAST International Symposium on Time-resolved Spectroscopy (Kawasaki, 1991) Organizer.
    • The 10th International Conference on Time-resolved Vibrational Spectroscopy (Okazaki, 2001) Co-chair.
    • The 20th International Conference on Raman Spectroscopy (Yokohama, 2006) Chair.
    • The 2nd International Congress on Ionic Liquids (Yokohama, 2007) Co-chair.
    • Advanced Spectroscopy and Imaging in Molecular Science (Hsinchu, Taiwan, 2010) Co-chair.
  3. Steering Committee Membership of International Conferences
    • International Conference on Time-resolved Vibrational Spectroscopy
    • Laser Applications in Life Sciences
    • International Conference on Raman Spectroscopy (2006-present, Steering Committee Chairman 2008-2010)
    • Asian Conference on Spectroscopy(2007-present, Steering Committee Founding Chairman)
    • European Congress on Molecular Spectroscopy(2008-present)
    • CODATA Executive Committee member (2010-present)
  4. Others
    • Director of the Chemical Society of Japan, 2000-2002
    • President of the Spectroscopical Society of Japan, 2003-2005
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Honors and Awards

  • Ramasay Fellow, 1977-79
  • Pittsburgh Conference Lectures, 1993
  • Meggers Award, Society for Applied Spectroscopy, 2005
  • The Spectroscopical Society of Japan Award, 2006
  • The Chemical Society of Japan Award, 2009
  • TRVS (Time-resolved Vibrational Spectroscopy) Award, 2009
  • Fellow of the Society for Applied Spectroscopy USA, 2010
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Invited Talks (from 2009)

» whole list (2010-1973)
  1. Deca-second Mitochondria Dynamics of Living Yeast Cells as Studied by Time- and Space-resolved Raman Spectroscopy,M. Kato, C. Onogi, H. Hamaguchi, The 22nd International Conference on Raman Spectroscopy, Boston (2010.8).
  2. Recent Developments in Space-resolved Raman Spectroscopy at Tokyo: Single Molecules, Nano-structures and Single Living Cells, Hiro-o Hamaguchi, Gordon Research Conference on Vibrational Spectroscopy, Bidderford, USA (2010.8)
  3. Raman and CARS: Which wins in microspectroscopy of living cells?, Hiro-o Hamaguchi, European Conference on Non-linear Optics and Spectroscopy, Bremen (2010.6)
  4. What Are Local Structures and Micro Molecular Environments in Ionic Liquids?, Hiro-o Hamaguchi, ACS Symposium, San Francisco (2010.3).
  5. Raman Spectroscopic View of Life, Hiro-o Hamaguchi, Indian Academy of Science Platinum Jubilee Meeting, Bangalore (2009.11).
  6. Living Cell Chemistry: Looking at Life with Chemical Eyes, Hiro-o Hamaguchi, Topical Problems in Biophotonics 2009, Nizhny Novgorod (2009.7).
  7. Nanoscopic Structure of Ionic Liquids, Hiro-o Hamaguchi, 3rd International Congress on Ionic Liquids, Cairns (2009.6).
  8. Toward Single Molecule and Single Cell Time-resolved Vibrational Spectroscopy,Hiro-o Hamaguchi, 14th International Conference on Time-resolved Vibrational Spectroscopy, Meredith NH, USA (2009.5).
  9. Can Raman Spectroscopy Image Life?, Hiro-o Hamaguchi, 9th National Institute for Basic Biology Symposium, Okazaki (2009.4).
  10. Can Raman Spectroscopy Measure and Quantify Life?,Hiro-o Hamaguchi, Physics of Qunatum Electronics Conference 2009, Snowbird (2009.1).
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Publications (from 2009)

» whole list (2011-1973)
  1. Protein Secondary Structure Imaging with Ultrabroadband Multiplex Coherent Anti-Stokes Raman Scattering (CARS) Microspectroscopy.
    Kotatsu Bito, Masanari Okuno, Hideaki Kano, Shihomi Tokuhara, Satoru Naito, Yoshinori Masukawa, Philippe Leproux, Vincent Couderc and Hiro-o Hamaguchi,
    J. Phys. Chem. B. , Accepted (2012).
  2. Two-step photoionization of trans-stilbene in acetonitrile via an ion-pair precursor studied with picosecond time-resolved absorption and Raman spectroscopies.
    Hiroko Miki, Kyousuke Yoshida, Chieko Kawate, Rintaro Shimada, Tomohisa Takaya, Koichi Iwata and Hiro-o Hamaguchi,
    Chem. Phys. Lett. , Accepted (2012).
  3. Rotational dynamics of solvated carbon dioxide studied by infrared, Raman, and time-resolved infrared spectroscopies and a molecular dynamics simulation.
    Kaori Watanabe, Hajime Okajima, Takuya Kato, and Hiro-o Hamaguchi,
    J. Chem. Phys., 136, 014508 (2012).
  4. Resonance Raman quantification of the redox state of cytochromes b and c in-vivo and in-vitro.
    Minoru Kakita, Venkatesh Kaliaperumal and Hiro-o Hamaguchi,
    J. Biophoton., 5, 20-24 (2012).
  5. Unusually long trans/gauche conformational equilibration time during the melting process of BmimCl, a prototype ionic liquid.
    Hajime Okajima and Hiro-o Hamaguchi,
    Chem. Lett., 40, 1308-1309 (2011).
  6. In vivo multimode Raman imaging reveals concerted molecular composition and distribution changes during yeast cell cycle.
    Chuan-Keng Huang, Hiro-o Hamaguchi and Shinsuke Shigeto,
    Chem. Comm., 47, 9423-9425 (2011).
  7. New opportunities offered by compact sub-nanosecond supercontinuum sources in ultrabroadband multiplex CARS microspectroscopy.
    Philippe Leproux, Vincent Couderc, Annalisa De Angelis, Masanari Okuno, Hideaki Kano and Hiro-o Hamaguchi,
    J. Raman spectrosc., 42, 1871-1874 (2011).
  8. Superresolution vibrational imaging by simultaneous detection of Raman and hyper-Raman scattering.
    Korenobu Matsuzaki, Rintaro Shimada and Hiro-o Hamaguchi,
    Opt. Lett., 36, 2545-2547 (2011).
  9. Quantitative Coherent Anti-Stokes Raman Scattering (CARS) Microscopy.
    James P. R. Day, Katrin F. Domke, Gianluca Rago, Hideaki Kano, Hiro-o Hamaguchi, Erik M. Vartiainen, and Mischa Bonn,
    J. Phys. Chem. B, 115, 7713-7725 (2011).
  10. 1064 nm deep near-infrared (NIR) excited Raman microspectroscopy for studying photolabile organisms.
    Masahiro Ando, Miwa Sugiura, Hidenori Hayashi, and Hiro-o Hamaguchi,
    Appl. Spectrosc., 65, 488-492 (2011).
  11. The gRaman spectroscopic signature of lifeh is closely related to haem function in budding yeasts.
    Liang-da Chiu and Hiro-o Hamaguchi,
    J. Biophoton., 4, 30-33 (2011).
  12. Solute-solvent intermolecular vibronic coupling as manifested by the molecular near-field effect in resonance hyper-Raman scattering.
    Rintaro Shimada and Hiro-o Hamaguchi,
    J. Chem. Phys., 134, 034516 (2011).
  13. Multifocus confocal Raman microspectroscopy for fast multimode vibrational imaging of living cells.
    Masanari Okuno and Hiro-o Hamaguchi,
    Opt. Lett., 35, 4096-4098 (2010).
  14. Ordering, interaction, and reactivity of the low-lying nπ* and ππ* excited triplet states of acetophenone derivatives.
    Sohshi Yabumoto, Shinsuke Shigeto, Yuan-Pern Lee and Hiro-o Hamaguchi
    Angew. Chem. Int. Ed., 49, 9201-9205 (2010).
  15. Differentiation of animal fats from different origins: use of polymorphic features detected by Raman spectroscopy.
    Michiyo Motoyama, Masahiro Ando, Keisuke Sasaki, and Hiro-o Hamaguchi,
    Appl. Spectrosc., 64, 1244-1250 (2010).
  16. Quantitative CARS molecular fingerprinting of single living cells with the use of the maximum entropy method.
    Masanari Okuno, Hideaki Kano, Philippe Leproux, Vincent Couderc, James P. R. Day, Mischa Bonn and Hiro-o Hamaguchi,
    Angew. Chem. Int. Ed., 49, 6773-6777 (2010).
  17. Triplet quantum chain process in the photoisomerization of 9-cis retinal as revealed by nanosecond time-resolved infrared spectroscopy.
    Tetsuro Yuzawa and Hiro-o Hamaguchi,
    J. Mol. Struc., 976, 414-418 (2010).
  18. In vivo resonance raman detection of ferrous cytochrome c from mitochondria of single living yeast cells.
    Chikao Onogi and Hiro-o Hamaguchi,
    Chem. Lett. , 39, 270-271 (2010).
  19. Visible nonlinear band-edge luminescence in ZnSe and CdS excited by a mid-infrared free-electron laser.
    Eiji Tokunaga, Naoto Sato, Jiro Korenaga, Takayuki Imai, Shin Sato and Hiro-o Hamaguchi,
    Opt. Rev. , 17, 341-345 (2010).
  20. Two different charge transfer states of photoexcited 9,9Œ-bianthryl in polar and nonpolar solvents characterized by nanosecond time-resolved near-IR spectroscopy in the 4500-10500 cm?1 region.
    Nobuyuki Asami, Tomohisa Takaya, Soshi Yabumoto, Shinsuke Shigeto, Hiro-o Hamaguchi and Koichi Iwata ,
    J. Phys. Chem. A , 114, 6351-6365 (2010).
  21. A near-infrared Raman spectroscopic study on the bovine lens applied to the solar radiation in Antarctica.
    Tatsuyuki Yamamoto, Keisuke Yoshikiyo, Young-Kun Min, Hiro-o Hamaguchi, Satoshi Imura, Sakae Kudoh, Tetsuya Takahashi and Naoyuki Yamamoto,
    J. Mol. Struct. , 968, 115-119 (2010).
  22. Study of the eRaman spectroscopic signature of lifef in mitochondria isolated from budding yeast.
    Liang-da Chiu, Masahiro Ando and Hiro-o Hamaguchi,
    J. Raman Spectrosc. , 41, 2-3 (2010).
  23. Raman spectra of isotope-substituted mitochondria of living budding yeast cells: possible origin of the "Raman spectroscopic signature of life".
    Chikao Onogi, Hajime Torii and Hiro-o Hamaguchi,
    Chem. Lett., 38, 898-890 (2009).
  24. Fast low frequency (down to 10 cm-1) multichannel Raman spectroscopy using an iodine vapor filter.
    Hajime Okajima and Hiro-o Hamaguchi,
    Appl. Spectrosc. , 63, 958-960 (2009).
  25. Photobleaching of the "Raman spectroscopic signature of life" and mitochondrial activity in rho- budding yeast cells.
    Chikao Onogi and Hiro-o Hamaguchi,
    J. Phys. Chem. B , 113, 10942-10945 (2009).
  26. Femtosecond time-resolved absorption anisotropy spectroscopy on 9,9'-bianthryl: Detection of partial intramolecular charge transfer in polar and nonpolar solvents.
    Tomohisa Takaya, Hiro-o Hamaguchi and Koichi Iwata,
    J. Chem. Phys., 130, 14501 (2009).
  27. Intermolecular interaction between W(CO)6 and alkane molecules probed by ultrafast vibrational energy relaxation: anomalously strong interaction between W(CO)6 and decane.
    Motohiro Banno, Koichi Iwata and Hiro-o Hamaguchi,
    J. Phys. Chem. A , 113, 1007-1011 (2009).
  28. Developments of Raman spectroscopy in the past 40 years: from a molecule to a living cell.
    Hiro-o Hamaguchi,
    Curr. Sci. , 97, 186-191 (2009).
  29. Ultrafast Protonation/Deprotonation Dynamics of N,N-Dimethylacetamide in Hydrochloric Acid As Studied by Raman Band Shape Analysis.
    Daisuke Watanabe and Hiro-o Hamaguchi,
    J. Phys. Chem. C , 27, 11662-11666 (2009).
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